Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5021 | 5021-30606 | Greece | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SG, L74I, M184V, T215F | Y181C | E6EK, K20R, V35T, T39A, K122E, I135T, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211A, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, G335D, M357S, G359S, T369A, A371V, I375V, A376V, T377M, T386A |
| >5021-30606| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEMII CQYVDDLYVGSDLEIGQHRAKIEELRAHLLAWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARSRSA HTNDVKQLAEVVQKVVMESIVIWGKAPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F, I84IV, L90M | L33F, F53L | L10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89M |
| >5021-30606| codons 1-99 PQITLWQRPILTVKVEGQPIEALLDTGADDTVFENINLPGRWKPVMIGGIGGLVKVRQYD QITIEICGKKAIGTVLVGPTPFNVIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |