<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5021 5021-30606 Greece 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82F, I84IV, L90M L33F, F53L L10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89M  
>5021-30606| codons 1-99
PQITLWQRPILTVKVEGQPIEALLDTGADDTVFENINLPGRWKPVMIGGIGGLVKVRQYD
QITIEICGKKAIGTVLVGPTPFNVIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69S_SG, L74I, M184V, T215F   Y181C   E6EK, K20R, V35T, T39A, K122E, I135T, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211A, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, G335D, M357S, G359S, T369A, A371V, I375V, A376V, T377M, T386A  
>5021-30606| codons 1-399
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV
FAIKKKDSSKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEMII
CQYVDDLYVGSDLEIGQHRAKIEELRAHLLAWGFFTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARSRSA
HTNDVKQLAEVVQKVVMESIVIWGKAPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006