Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5018 | 5018-30606 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219N | Y181C, G190A | T27S, V35L, T39A, K43E, E44A, R83K, K102Q, V118I, D123E, E138ED, V179VI, Q197E, T200A, E203K, Q207E, H208Y, R211K, K223E, A272P, K281R, I293V, E297R, V317VA, I326IV, Q334P, M357T, G359S, T369A, A371V, A376T, T377Q, K395R, E396D |
| >5018-30606| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALLEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNDTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVASDLEIGEHRAKIKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTREAE LELAENREILKEPVHGAYYDPSKDLVAEIQKQGPGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLAEVVQKITQESIVIWGKTPKFKLPIQRDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IV, I84V, L90M | L10FI, L33F, F53FL, T74P, L89LV | I13V, L19LI, N37HY, K55R, D60E, I62V, L63P, I66F, H69I, A71T, I72E, V77I, Q92K |
| >5018-30606| codons 1-99 PQITLWQRPIVTVKIGGQIKEALLDTGADDTVFEEMYLPGRWKPKLIGGIGGLVRVRQYE QVPIEFCGIKTEGPVLIGPTPVNVIGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |