<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5018 5018-30606 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184MV, L210W, T215Y K219N Y181C, G190A   T27S, V35L, T39A, K43E, E44A, R83K, K102Q, V118I, D123E, E138ED, V179VI, Q197E, T200A, E203K, Q207E, H208Y, R211K, K223E, A272P, K281R, I293V, E297R, V317VA, I326IV, Q334P, M357T, G359S, T369A, A371V, A376T, T377Q, K395R, E396D  
>5018-30606| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALLEICAELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNDTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
CQYVDDLYVASDLEIGEHRAKIKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGAYYDPSKDLVAEIQKQGPGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLAEVVQKITQESIVIWGKTPKFKLPIQRDTWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54IV, I84V, L90M L10FI, L33F, F53FL, T74P, L89LV I13V, L19LI, N37HY, K55R, D60E, I62V, L63P, I66F, H69I, A71T, I72E, V77I, Q92K  
>5018-30606| codons 1-99
PQITLWQRPIVTVKIGGQIKEALLDTGADDTVFEEMYLPGRWKPKLIGGIGGLVRVRQYE
QVPIEFCGIKTEGPVLIGPTPVNVIGRNVMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006