<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5017 5017-30530 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, I84V Q58E L10I, T12P, K20KR, E35D, M36I, R57K, D60E, I62V, L63P, A71V, V82I, L89M, I93L  
>5017-30530| codons 1-99
PQITLWQRPIVPIKIGGQLREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVKEYE
QVPIEICGHKVIGTVVVGPTPINVIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M, K219N K103N   K20R, K43E, E44A, V60I, W88C, V118I, K122E, I135L, I142V, I178L, D192N, G196E, T200A, E203K, H208Y, R211K, K223E, L228H, A272S, V276I, L283I, A288S, I293V, E297A, V317A, D324E, Q334DH, A371V, I375A, T386TA  
>5017-30530| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFCEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYVGSNLEIEQHRAKIKELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKIKQLCKLIRGTKSLTEVVPLTAEAE
LELAENREILKEPVHGAYYDPSKELIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEVVQKAATESIVIWGKAPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006