Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5017 | 5017-30530 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V | Q58E | L10I, T12P, K20KR, E35D, M36I, R57K, D60E, I62V, L63P, A71V, V82I, L89M, I93L |
| >5017-30530| codons 1-99 PQITLWQRPIVPIKIGGQLREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVKEYE QVPIEICGHKVIGTVVVGPTPINVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | K103N | K20R, K43E, E44A, V60I, W88C, V118I, K122E, I135L, I142V, I178L, D192N, G196E, T200A, E203K, H208Y, R211K, K223E, L228H, A272S, V276I, L283I, A288S, I293V, E297A, V317A, D324E, Q334DH, A371V, I375A, T386TA |
| >5017-30530| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFCEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVGSNLEIEQHRAKIKELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKIKQLCKLIRGTKSLTEVVPLTAEAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKAATESIVIWGKAPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |