<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5016 5016-30516 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V L24I, L33F, K43T L10V, T12P, I15V, G16E, K20M, N37H, I64V, A71T, I72IR, T74A, T91A  
>5016-30516| codons 1-99
PQITLWQRPVVPIKVEGQLMEALIDTGADDTVFEEMHLPGRWTPKLIGGIGGFVKVRQYD
QILVEICGHKTRGAVLVGPTPANVIGRNLLAQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LI, L210W, T215Y   K103KN   V35I, T39A, K43E, V60I, V118I, K122E, I135L, S162C, G196E, A272P, V292I, I329V, G335S, R358K, G359S, V365I, A371V, A376S, K390R  
>5016-30516| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEEGKISKIGPENPYNTPI
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQSQWTYQIYQEPFKNLKTGKYARMKSA
HTNDIKQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006