Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5016 | 5016-30516 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L24I, L33F, K43T | L10V, T12P, I15V, G16E, K20M, N37H, I64V, A71T, I72IR, T74A, T91A |
| >5016-30516| codons 1-99 PQITLWQRPVVPIKVEGQLMEALIDTGADDTVFEEMHLPGRWTPKLIGGIGGFVKVRQYD QILVEICGHKTRGAVLVGPTPANVIGRNLLAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, L210W, T215Y | K103KN | V35I, T39A, K43E, V60I, V118I, K122E, I135L, S162C, G196E, A272P, V292I, I329V, G335S, R358K, G359S, V365I, A371V, A376S, K390R |
| >5016-30516| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQSQWTYQIYQEPFKNLKTGKYARMKSA HTNDIKQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |