Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5014 | 5014-30514 | Greece | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90LM | L10F, Q58E | I13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83S |
| >5014-30514| codons 1-99 PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVREYE QVPVEICGHKAIGTVLVGPTPASIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K11KR, V35T, K49R, V60I, V118I, D121C, K122E, D123DE, E169D, D177E, I178L, V179VI, T200I, Q207A, F214L, V245K, K249Q, D250E, A272P, K277R, T286A, I293V, E297A, Q334L, P345A, G359S, A371V, I375V, K390R |
| >5014-30514| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL CEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPELII YQYMDDLYVGSDLEIGQHRIKIEELRAHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEQESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEAFKNLKTGKYARMRSA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |