<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5014 5014-30514 Greece 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90LM L10F, Q58E I13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83S  
>5014-30514| codons 1-99
PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVREYE
QVPVEICGHKAIGTVLVGPTPASIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219Q     K11KR, V35T, K49R, V60I, V118I, D121C, K122E, D123DE, E169D, D177E, I178L, V179VI, T200I, Q207A, F214L, V245K, K249Q, D250E, A272P, K277R, T286A, I293V, E297A, Q334L, P345A, G359S, A371V, I375V, K390R  
>5014-30514| codons 1-399
PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
CEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPELII
YQYMDDLYVGSDLEIGQHRIKIEELRAHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIKLPEQESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEAFKNLKTGKYARMRSA
HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006