<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5013 5013-30513 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y   G190C   V35VL, T39TAEK, K43KDEN, S68G, K101Q, V118I, K122E, I135IT, I142IL, V189VI, G196E, Q197K, Q207E, V245EK, I293V, T296S, E297R, Q334E, M357T, A376S, S379C, V381I, K390R, E399D  
>5013-30513| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELENEGKISKIGPENPYNTPV
FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGLRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYICSDLEIEKHRTKIEELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLSREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKISTECIIIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M Q58E, G73S L10I, I15V, G16A, L19P, K20M, L24F, M36V, K55KR, R57K, D60E, I62V, L63P, A71V, I72L  
>5013-30513| codons 1-99
PQITLWQRPIVTIKVAGQPMEALFDTGADDTVLEEVNLPGRWKPKIIGGIGGFVRVKEYE
QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006