Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5013 | 5013-30513 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58E, G73S | L10I, I15V, G16A, L19P, K20M, L24F, M36V, K55KR, R57K, D60E, I62V, L63P, A71V, I72L |
| >5013-30513| codons 1-99 PQITLWQRPIVTIKVAGQPMEALFDTGADDTVLEEVNLPGRWKPKIIGGIGGFVRVKEYE QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | G190C | V35VL, T39TAEK, K43KDEN, S68G, K101Q, V118I, K122E, I135IT, I142IL, V189VI, G196E, Q197K, Q207E, V245EK, I293V, T296S, E297R, Q334E, M357T, A376S, S379C, V381I, K390R, E399D |
| >5013-30513| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELENEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGLRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYICSDLEIEKHRTKIEELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLSREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKISTECIIIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |