Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5012 | 5012-30509 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67~, K70R, L74I, T215F | T69G, K219Q | V108I | K20R, T39D, V118I, K122E, I135T, T139TI, I142L, F214L, K223Q, L228H, T240TA, Q242H, V245M, A272P, R284RK, T286TA, I293V, K311R, V317VAG, M357I, G359S, A360T, V365I |
| >5012-30509| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICDELEKEGKISKIGPENPYNTPV FAIKKK~SGRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNEIPGLRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPDKWA VHPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVPLTEEAE LELAENREILREPVHGGYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARIRST HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, K43T, G48W, F53L | L10I, T12N, I13V, M36L, I62V, L63T, T74A, L89I |
| >5012-30509| codons 1-99 PQITLWQRPIVNVKIGGQLKEALLDTGADDTVFEELNLPGRWTPKMIWGIGGLVKVRQYD QVTIEICGHKAIGAVLVGPTPANIIGRNIMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |