Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5011 | 5011-31014 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | V11I, L24I, N83D | I13V, K20R, A22V, E35D, M36I, K55R, R57K, Q61E, I62V, L63P, A71T, I72V | T91TCS |
| >5011-31014| codons 1-99 PQITLWQRPLITVKIGGQLREVLIDTGADDTVLEDINLPGRWKPKIIGGIGGFVRVKQYD EVPIEICGHKTVGTVLVGPTPVDVIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | V75A, K219R | Y181C, G190A | V108I | K43E, E44D, K101Q, V118I, D121H, K122E, S162C, R172K, D177E, R211K, H221Y, A272P, A288S, I293V, Q334E, P345E, F346H, R356K, G359S, A360T, V365I, K390R, E399D |
| >5011-31014| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKVADFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPEIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEEHKNLKTGKYAKMRST HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |