<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5011 5011-30509 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LV, M184MIV, L210W, T215Y V75A, K219KR Y181C, G190A V108VI K43E, E44D, K101Q, V118I, D121H, K122E, S162C, R172K, D177E, R211K, H221Y, A272P, A288S, I293V, Q334E, P345E, F346H, R356K, G359S, A360T, V365I, K390R, E399D  
>5011-30509| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVADFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL
HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPEIVI
CQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEEHKNLKTGKYAKMRST
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V L10FI, V11VI, L24I, F53L I13IV, K20R, E35D, M36I, R57K, Q61E, I62V, L63P, A71T, I72V  
>5011-30509| codons 1-99
PQITLWQRPIITVKIGGQLREALIDTGADDTVLEDINLPGRWKPKIIGGIGGLIKVKQYD
EVPIEICGHKTVGTVLVGPTPVNVIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006