Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5010 | 5010-30820 | Greece | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219E | K101P, G190A | V35IT, T39TA, V60I, K66KR, V118I, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, L228H, V245S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376AV, T377M, E399D |
| >5010-30820| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKRNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIII YQYMDDLYVASDLEIGQHRTKIEELRAHLWSWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPISLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVKQLAEVVQKVVMESIVIWGKTPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I54V, V82A | Q58E | L10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71T |
| >5010-30820| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVLEDIDLPGKWKPKLIGGIGGFVKVREYD QVPIEICGHKTIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |