<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5010 5010-30820 Greece 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y K219E K101P, G190A   V35IT, T39TA, V60I, K66KR, V118I, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, L228H, V245S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376AV, T377M, E399D  
>5010-30820| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI
FAIKKRNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIII
YQYMDDLYVASDLEIGQHRTKIEELRAHLWSWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPISLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVKQLAEVVQKVVMESIVIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MIL, I54V, V82A Q58E L10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71T  
>5010-30820| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVLEDIDLPGKWKPKLIGGIGGFVKVREYD
QVPIEICGHKTIGTVLVGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006