Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2103 | CA7759 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 313 |
| 2 | AZT+DDI | 52 |
| 3 | AZT+DDC | 52 |
| 4 | AZT+D4T | 52 |
| 5 | 3TC+D4T+SQV | 52 |
| 6 | 3TC+D4T+IDV | 61 |
| 7 | 3TC+D4T+IDV+SQV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, V82A, L90M | L10I, I15V, E35D, M36I, N37S, R41K, L63P, A71V, I93L |
| >CA7759| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDISLPGKWKPKMIVGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215F | A62V, K219Q | K103N | V35L, K64KR, K122E, K173E, I178L, V179VI, D218E, L228H |
| >CA7758| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FVIRKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDLII YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |