<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5008 5008-30627 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82A L24I, K43T L10I, K20R, E35D, M36I, K55KR, D60E, I62V, L63E, I64V, A71V, I93L  
>5008-30627| codons 1-99
PQITLWQRPIVTIKIGGQLREALIDTGADDTVLEDINLPGRWTPKIIGGIGGFARVRQYE
QVEVEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, Q151M, T215CY V75I, F116Y, K219Q Y181C, G190AS   K101Q, V118I, D121H, K122E, I135L, R172K, I178L, R211K, F214L, V245K, I293V, K347KR, R356RK, G359S, K390R  
>5008-30627| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYYSIPL
HEDFRKYTAFTIPSLNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDLVI
CQYMDDLYVSSDLEIGQHRTKIEELRQHLLKWGLYTPDQKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFRNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006