Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5008 | 5008-30627 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82A | L24I, K43T | L10I, K20R, E35D, M36I, K55KR, D60E, I62V, L63E, I64V, A71V, I93L |
| >5008-30627| codons 1-99 PQITLWQRPIVTIKIGGQLREALIDTGADDTVLEDINLPGRWTPKIIGGIGGFARVRQYE QVEVEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, T215CY | V75I, F116Y, K219Q | Y181C, G190AS | K101Q, V118I, D121H, K122E, I135L, R172K, I178L, R211K, F214L, V245K, I293V, K347KR, R356RK, G359S, K390R |
| >5008-30627| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYYSIPL HEDFRKYTAFTIPSLNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDLVI CQYMDDLYVSSDLEIGQHRTKIEELRQHLLKWGLYTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFRNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |