Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5007 | 5007-30626 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_EG, V75M, L210W, T215Y | D67S | K103N, Y181C | P4PS, T27TS, T39A, K122E, R211K, L228H, V245E, A288S, I293V, E297R, Q334E, M357S, A360T, A376S, K390R | S68Q |
| >5007-30626| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKSQAKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARSRGT HTNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82A | L33I | L10I, I13V, L19I, K20M, E35DN, M36I, N37D, I62V, L63P, I64V, T74S, N83S, T91TS |
| >5007-30626| codons 1-99 PQITLWQRPIVTVKIGGQIMEALLDTGADDTVIENIDLPGRWKPKIIVGIGGFTKVRQYD QVPVEICGHKAIGSVLVGPTPASIIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |