<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5005 5005-30422 Greece 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54IATV, V82VA, L90LM L33LF L10LI, I13V, K14KR, L19LI, K20KR, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89IM  
>5005-30422| codons 1-99
PQITLWQRPIVTVRIGGQIREALLDTGADDTVFEDINLPGKWKPRMIGGIGGFVKVKQYD
QIPIEICGKKAIGTVLVGPTPANIIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y K219KE     K32KI, V35T, T39TI, V60I, V118VI, K122E, D123N, T139K, K173S, Q174K, V179I, Q207A, R211K, L228LH, V245K, D250E, K259KR, T286TA, E291D, V292I, I293V, P294T, E305ED, E312ED, A327AS, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, I393IT, A400T Y115YH
>5005-30422| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIIALTEICIELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAHFSIPL
DENFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPDIII
YQYMDDLYVGSDLEIGQHRTKIEELRAHLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIKLPEKESWTVNDIQRLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE
LELADNREILKDPVHGVYYDPSKDLISEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVKQLAEVVQKVVMESIVIWGKTPKFKLPTQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006