Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5004 | 5004-30421 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, I84V | V11I, L33I, K43T | L10I, I13V, A22V, E35D, N37T, R41K, D60E, Q61E, I62V, L63P, I64V, V77VI |
| >5004-30421| codons 1-99 PQITLWQRPIITVKIGGQLKEVLLDTGADDTIIEDMTLPGKWTPKIVGGIGGFVKVRQYE EVPVEICGHKAIGTVLIGPTPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75L | V106A | F227L | V35T, T39A, S48T, V60I, V118I, D123E, T139K, G196E, E203D, Q207R, R211RK, K277R, I293V, E297A, K311R, S322T, V365I, A376S, T386L, K390R, Q394H, E396D, E399D |
| >5004-30421| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKITKIGPENPYNTPI FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DKEFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIDELRRHLWKWGFYTPDKKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILREPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTEAVQKISTESIVIWGKLPKFRLPIHKDTWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |