Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5003 | 5003-30421 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82S, L90M | L10F, V11I, K43KT, L89V | I13V, I15V, Q18H, K20I, E35D, M36I, K55KR, I62V, L63P, A71I, I72V |
| >5003-30421| codons 1-99 PQITLWQRPFITVKVGGHLIEALLDTGADDTVLEDINLPGRWTPKIVGGIGGFVRVRQYD QVPIEICGHKIVGTVLVGPTPSNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69TADN, L74I, L210W, T215F | K219N | K20R, V35I, E40F, K43E, I94IL, V118I, K122E, I135L, K173N, Q174K, G196E, I202V, H208Y, R211K, R284K, A288S, I293V, P294T, I326T, Q334N, M357T, A376T, T386V |
| >5003-30421| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSNKWRKIVDFRELNKRTQDFWEVQLGLPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNKNPDIVI YQYMDDLYVGSDLEIEQHRTKVEELRQYLWKWGFFTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGNGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKITTESIVIWGKVPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |