Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5002 | 5002-30415 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, T215Y | N348I | K103N, Y181C, G190A | V35T, T39A, V60I, V118VI, K122E, D123DN, I135T, I142V, D177E, T286A, A288S, I293V, E297R, L301I, I341F, E344D, R356K, K390R | L228RS |
| >5002-30415| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFSWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVVPLTREAE IELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQFYQDPFKILKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, I15V, M36MI, R41K, L63P, I72V, V77I |
| >5002-30415| codons 1-99 PQITLWQRPIVTVKVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |