Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5001 | 5001-30415 | Greece | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | D67DE | K103N | A98G | V35T, E36A, T39E, E44ED, S68G, K122E, D123G, I135T, K173T, D177E, T200A, E203D, Q207E, R211K, V245Q, A272P, K277KR, T286A, E291D, V292I, I293V, D324E, I329L, Q334H, G335D, R356K, R358RK, G359T, I382IL, K390R |
| >5001-30415| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEELEKDGKISKIGPENPYNTPV FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI YQYVDDLYVGSDLEIGQHRAKIDELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGHDQWTYQIYQEPFKNLKTGKYAKMKTA HTNDVKQLTEAVQKIATESIVLWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, V82A | L10F, L33LF | I13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93IL |
| >5001-30415| codons 1-99 PQITLWQRPFVTVKVAGQIKEALLDTGADDTVFQELSLPGKWKPKIIGGIAGFINVRQYD QVLIEICGKKAIGSVVVGPTPANIIGRNILTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |