<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5001 5001-30415 Greece 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V, V82A L10F, L33LF I13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93IL  
>5001-30415| codons 1-99
PQITLWQRPFVTVKVAGQIKEALLDTGADDTVFQELSLPGKWKPKIIGGIAGFINVRQYD
QVLIEICGKKAIGSVVVGPTPANIIGRNILTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y D67DE K103N A98G V35T, E36A, T39E, E44ED, S68G, K122E, D123G, I135T, K173T, D177E, T200A, E203D, Q207E, R211K, V245Q, A272P, K277KR, T286A, E291D, V292I, I293V, D324E, I329L, Q334H, G335D, R356K, R358RK, G359T, I382IL, K390R  
>5001-30415| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEELEKDGKISKIGPENPYNTPV
FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI
YQYVDDLYVGSDLEIGQHRAKIDELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGHDQWTYQIYQEPFKNLKTGKYAKMKTA
HTNDVKQLTEAVQKIATESIVLWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006