Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4394 | 4394-30912 | Austria | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, L210W, T215Y | K103N, Y181C | K20R, I31L, V35T, T39E, E40D, V60I, V90VI, V106I, K122E, D123DGNS, I142V, D177E, G196K, T200A, E203D, Q207E, R211K, L228R, V245Q, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, L301M, I329V, Q334L, G335E, F346H, K350R, R356K, M357R, R358G, G359S, A360T, A371V, T386V, K390R |
| >4394-30912| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKLKALTEICEDMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIKQHRAKIDELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIQLPEKENWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE MELAENREILKEPVHGVYYDPSKDLIAEVQKQGLEQWTYQIYQEPHKNLRTGKYAKRGST HTNDVKQLTEVVQKIATESIVIWGKVPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82F | L10I, I13V, G16GA, K20I, E35D, M36I, L63P, H69K, T74TS, L89M |
| >4394-30912| codons 1-99 PQITLWQRPIVTVKIAGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGKKAIGSVVVGPTPFNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |