<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4394 4394-30912 Austria 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82F   L10I, I13V, G16GA, K20I, E35D, M36I, L63P, H69K, T74TS, L89M  
>4394-30912| codons 1-99
PQITLWQRPIVTVKIAGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGKKAIGSVVVGPTPFNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, L210W, T215Y   K103N, Y181C   K20R, I31L, V35T, T39E, E40D, V60I, V90VI, V106I, K122E, D123DGNS, I142V, D177E, G196K, T200A, E203D, Q207E, R211K, L228R, V245Q, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, L301M, I329V, Q334L, G335E, F346H, K350R, R356K, M357R, R358G, G359S, A360T, A371V, T386V, K390R  
>4394-30912| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKLKALTEICEDMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSITVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVGSDLEIKQHRAKIDELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIQLPEKENWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
MELAENREILKEPVHGVYYDPSKDLIAEVQKQGLEQWTYQIYQEPHKNLRTGKYAKRGST
HTNDVKQLTEVVQKIATESIVIWGKVPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006