Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4392 | 4392-30722 | Austria | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K219R | K103S, G190A | A98G, Y318F | K43Q, E44D, V60I, V118I, D123E, I135V, I142V, S162Y, G196E, T200A, E203D, H208Y, R211K, W212C, L228H, V245Q, I293V, E297EK, Q334E, G359S, K390R, E399D |
| >4392-30722| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKSKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIEQHRAKIDELRQYLWKCGFYTPDRKHQKEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, V82A, L90M | V32A, L33F, Q58E | L10V, I13V, G16A, K20R, E35D, M36I, N37E, K55R, D60E, Q61E, I62V, L63P, A71V, L89M, I93L |
| >4392-30722| codons 1-99 PQITLWQRPVVTVKIAGQLREALLDTGADDTAFEDIELPGRWKPKIIGGIGGFIRVREYE EVPIEICGHKVIGTVVVGPTPANIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |