<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4392 4392-30722 Austria 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y V75M, K219R K103S, G190A A98G, Y318F K43Q, E44D, V60I, V118I, D123E, I135V, I142V, S162Y, G196E, T200A, E203D, H208Y, R211K, W212C, L228H, V245Q, I293V, E297EK, Q334E, G359S, K390R, E399D  
>4392-30722| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKSKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIEQHRAKIDELRQYLWKCGFYTPDRKHQKEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVFYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V, V82A, L90M V32A, L33F, Q58E L10V, I13V, G16A, K20R, E35D, M36I, N37E, K55R, D60E, Q61E, I62V, L63P, A71V, L89M, I93L  
>4392-30722| codons 1-99
PQITLWQRPVVTVKIAGQLREALLDTGADDTAFEDIELPGRWKPKIIGGIGGFIRVREYE
EVPIEICGHKVIGTVVVGPTPANIIGRNMMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006