Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4321 | 4321-31001 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LIV, L210W, T215Y | V75L | K101E, G190S | A98G | K11R, K20KR, V35L, K43E, I94L, V118VI, D123E, D177E, V179I, I195L, G196E, T200TI, A272P, E291D, E297Q, M357V, G359S, K366R, E370D, A376T, S379C, T386A, K390R |
| >4321-31001| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALLEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVLDFRELNKRTQDFWEVQLGLPHPGGLEKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYMDDLYVSSDLELEQHRIKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRSA HTNDVRQLTDAVQKITTECIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50L, I54IV, V82A, L90M | L23LI, L33LF, Q58E | L10V, K55KR, D60E, L63P, A71V, N83NS, I93L | T80TP |
| >4321-31001| codons 1-99 PQITLWQRPVVTIKIGGQLKEAILDTGADDTVFEEMNLPGRWKPKLIGGLGGFVRVREYE QIPIEICGHKVIGTVLVGPPPASIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |