<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4321 4321-31001 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LIV, L210W, T215Y V75L K101E, G190S A98G K11R, K20KR, V35L, K43E, I94L, V118VI, D123E, D177E, V179I, I195L, G196E, T200TI, A272P, E291D, E297Q, M357V, G359S, K366R, E370D, A376T, S379C, T386A, K390R  
>4321-31001| codons 1-399
PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALLEICTELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVLDFRELNKRTQDFWEVQLGLPHPGGLEKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
YQYMDDLYVSSDLELEQHRIKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTQEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRSA
HTNDVRQLTDAVQKITTECIVIWGKAPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I50L, I54IV, V82A, L90M L23LI, L33LF, Q58E L10V, K55KR, D60E, L63P, A71V, N83NS, I93L T80TP
>4321-31001| codons 1-99
PQITLWQRPVVTIKIGGQLKEAILDTGADDTVFEEMNLPGRWKPKLIGGLGGFVRVREYE
QIPIEICGHKVIGTVLVGPPPASIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006