Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4315 | 4315-30930 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | G190Q | K20R, K43Q, V60I, T69N, V118I, I135T, E138A, M164L, E203A, Q207E, F214L, L228LH, V245VE, A272P, K277R, E297EK, D324E, M357T, K366R, K390R, K395R, E399D |
| >4315-30930| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEQEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSLTKILEPFRKQNPDIVI YQYMDDLYVQSDLEIGQHRTKIAELREHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, G73S | T12S, I15V, L19I, N37S, R57K, I62V, L63P, A71V, I93L | K20N |
| >4315-30930| codons 1-99 PQITLWQRPFVSIKVGGQINEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFVKVKQYD QVPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |