<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4314 4314-30925 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M V11VI, L33F, Q58E, G73T L10I, T12P, I13V, K14R, K20R, E34V, E35D, M36I, N37S, R41K, R57K, D60E, Q61E, I62V, L63P, I66IV, A71V, I72T, I93L  
>4314-30925| codons 1-99
PQITLWQRPIIPVRIGGQLREALLDTGADDTVFVDISLPGKWKPKMIGGIGGFVKVKEYE
EVPIEVCGHKVTTTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Y115F, Q151M, M184V A62AV, V75I, F77L, F116Y, K219E K103N   E6EK, V35I, T39TA, S68G, V118I, K122E, I135T, T200E, I202V, L210F, F214L, L228Q, V245MT, A288S, E297K, V317A, I326V, T386I  
>4314-30925| codons 2-400
ISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPVF
VIKKKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPLD
EDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYVDDLYVGSDLEIGQHREKVEELRQHLFRWGLTTPDEKHQKEPPFQWMGYELHPDKWTV
QPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTKEAEL
ELAENREILKEPVHGAYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAH
TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006