Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4314 | 4314-30925 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | V11VI, L33F, Q58E, G73T | L10I, T12P, I13V, K14R, K20R, E34V, E35D, M36I, N37S, R41K, R57K, D60E, Q61E, I62V, L63P, I66IV, A71V, I72T, I93L |
| >4314-30925| codons 1-99 PQITLWQRPIIPVRIGGQLREALLDTGADDTVFVDISLPGKWKPKMIGGIGGFVKVKEYE EVPIEVCGHKVTTTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62AV, V75I, F77L, F116Y, K219E | K103N | E6EK, V35I, T39TA, S68G, V118I, K122E, I135T, T200E, I202V, L210F, F214L, L228Q, V245MT, A288S, E297K, V317A, I326V, T386I |
| >4314-30925| codons 2-400 ISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPVF VIKKKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIY QYVDDLYVGSDLEIGQHREKVEELRQHLFRWGLTTPDEKHQKEPPFQWMGYELHPDKWTV QPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTKEAEL ELAENREILKEPVHGAYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAH TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |