Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4313 | 4313-30925 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | A62V, K219N | K103N | T39TA, K43E, E44A, K64KR, V106I, V118I, K122E, I135T, S162A, D177DN, G196GE, E203EK, Q207E, H208HY, D218DE, K223KQ, V245EK, K277R, T286A, I293V, E297K, D324E, G333E, R356RK, G359S, A371V, I375V, T377M, T386I, K390R |
| >4313-30925| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FVIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIEQHRTKIKELREYLWRWGFYTPENKHQQEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKVAMESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54IV, L76LV, I84V, L90M | L10FI, V11I, G73T | T12TP, I13V, I15V, L19IM, K20I, E34Q, M36I, N37NS, I62V, L63P, I64V, A71AITV, I72T, I93L |
| >4313-30925| codons 1-99 PQITLWQRPIIPVKVGGQMIEALLDTGADDTVLQEISLPGRWKPKIIGGIGGFVKVRQYD QVPVEICGHKVTTTVVVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |