<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4313 4313-30925 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y A62V, V75T, K219N K103N   T39TA, K43E, E44A, K64KR, V106I, V118I, K122E, I135T, S162A, D177DN, G196GE, E203EK, Q207E, H208HY, D218DE, K223KQ, V245EK, K277R, T286A, I293V, E297K, D324E, G333E, R356RK, G359S, A371V, I375V, T377M, T386I, K390R  
>4313-30925| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV
FVIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPNIVI
YQYVDDLYVGSDLEIEQHRTKIKELREYLWRWGFYTPENKHQQEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEVVQKVAMESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54IV, L76LV, I84V, L90M L10FI, V11I, G73T T12TP, I13V, I15V, L19IM, K20I, E34Q, M36I, N37NS, I62V, L63P, I64V, A71AITV, I72T, I93L  
>4313-30925| codons 1-99
PQITLWQRPIIPVKVGGQMIEALLDTGADDTVLQEISLPGRWKPKIIGGIGGFVKVRQYD
QVPVEICGHKVTTTVVVGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006