Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4312 | 4312-30915 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F | K20I, L24M, E34Q, M36MI, R57RK, I62V, L63P, I64V, G73I, V77VI, I85V |
| >4312-30915| codons 1-99 PQITLWQRPFVTIKIGGQLIEALMDTGADDTVLQEINLPGRWKPKIVGGIGGFMKVKQYD QVPVEICGHKAIITVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | F77L, K219N | A98G | V35I, E44D, V118I, K122E, I135M, S162C, H208Y, R211K, D218E, L228H, Q242H, A272P, V276T, K277R, L283I, A288S, R356K, G359S, A376V, S379C, T386A |
| >4312-30915| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLMDLRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPENKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKSLTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIVTECIVIWGKAPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |