Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4310 | 4310-30821 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, G73GS | L10I, I13V, G16A, K55R, R57K, I62V, L63PS, C67Y, A71T, I72IT |
| >4310-30821| codons 1-99 PQITLWQRPIVTVKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFVRVKQYD QVSIEIYGHKTTSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K20R, V35VEIK, T39A, E44D, V118I, K122E, I142T, I202V, A272AP, K275KR, K281R, T286A, E297K, A304E, I329L, Q334DH, R356K, M357T, T362S, Q367E, T369V, I375V, K390KR |
| >4310-30821| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCRLLRGAKALTEVIPLTKEAE LELEENREILKEPVHGVYYDPSKDLIAELQKQGHGQWTYQIYQEPFKNLKTGKYAKTRGA HSNDVKELVEAVQKVATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |