<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4310 4310-30821 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L33F, G73GS L10I, I13V, G16A, K55R, R57K, I62V, L63PS, C67Y, A71T, I72IT  
>4310-30821| codons 1-99
PQITLWQRPIVTVKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFVRVKQYD
QVSIEIYGHKTTSTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y       K20R, V35VEIK, T39A, E44D, V118I, K122E, I142T, I202V, A272AP, K275KR, K281R, T286A, E297K, A304E, I329L, Q334DH, R356K, M357T, T362S, Q367E, T369V, I375V, K390KR  
>4310-30821| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCRLLRGAKALTEVIPLTKEAE
LELEENREILKEPVHGVYYDPSKDLIAELQKQGHGQWTYQIYQEPFKNLKTGKYAKTRGA
HSNDVKELVEAVQKVATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006