Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4303 | 4303-30815 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219DN | Y181C, G190A | A98G, F227FL | V35I, K43N, E44D, V90I, K101Q, V118I, K122E, I142V, E169D, R172RK, T200A, E203K, Q207D, H208Y, R211K, K223E, L228H, Q242H, A272P, K277R, T286A, V292I, I293V, E297A, V317VA, Q334E, M357S, K366KR, A376S, A400S |
| >4303-30815| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPGGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFKKQNPDIVI CQYMDDLYVASDLEIGQHRAKIKELRDYLWKWGFYTPDNKHQEEPPLHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVRQLTEAVQKISTESIVIWGKTPKFKLPIQKETWES |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10FI, Q58QE, G73T | V11VL, I13V, K20I, E35N, M36I, N37D, K55R, D60E, I62IV, L63P, I64V, A71AITV, I72K |
| >4303-30815| codons 1-99 PQITLWQRPILTVKIGGQLIEALLDTGADDTVLENIDLPGRWKPKIIGGIGGFVRVREYE QVPVEICGHKVKTTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |