<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4303 4303-30815 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10FI, Q58QE, G73T V11VL, I13V, K20I, E35N, M36I, N37D, K55R, D60E, I62IV, L63P, I64V, A71AITV, I72K  
>4303-30815| codons 1-99
PQITLWQRPILTVKIGGQLIEALLDTGADDTVLENIDLPGRWKPKIIGGIGGFVRVREYE
QVPVEICGHKVKTTVLVGPTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219DN Y181C, G190A A98G, F227FL V35I, K43N, E44D, V90I, K101Q, V118I, K122E, I142V, E169D, R172RK, T200A, E203K, Q207D, H208Y, R211K, K223E, L228H, Q242H, A272P, K277R, T286A, V292I, I293V, E297A, V317VA, Q334E, M357S, K366KR, A376S, A400S  
>4303-30815| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPGGLQKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFKKQNPDIVI
CQYMDDLYVASDLEIGQHRAKIKELRDYLWKWGFYTPDNKHQEEPPLHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIVPLTAEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARSRGA
HTNDVRQLTEAVQKISTESIVIWGKTPKFKLPIQKETWES

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006