Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4302 | 4302-30806 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, L76V, V82A, I84V | L33F, F53L | L10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93L |
| >4302-30806| codons 1-99 PQITLWQRPIVTVKIEGQLMEALLDTGADDTVFEEVNLPGRWKPKMIMGIGGLVKVRQYD QVTIEICGRKVIGAVVVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | A98AG | E6EK, V35VI, K102KQ, V106VI, V118VI, K122E, I135V, S162C, R172RK, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, A272P, K277R, L283I, R284K, T286A, I293V, E297KQ, D324E, I329L, M357I, G359GS |
| >4302-30806| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKQKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGAKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARIRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |