<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4302 4302-30806 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54V, L76V, V82A, I84V L33F, F53L L10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93L  
>4302-30806| codons 1-99
PQITLWQRPIVTVKIEGQLMEALLDTGADDTVFEEVNLPGRWKPKMIMGIGGLVKVRQYD
QVTIEICGRKVIGAVVVGPTPANVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219N   A98AG E6EK, V35VI, K102KQ, V106VI, V118VI, K122E, I135V, S162C, R172RK, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, A272P, K277R, L283I, R284K, T286A, I293V, E297KQ, D324E, I329L, M357I, G359GS  
>4302-30806| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKQKKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGAKALTEVVPLTQEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARIRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006