Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4300 | 4300-30729 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V | L100I, K103N | I2IV, E6EK, K32R, V35L, V118VI, K122E, E138EQ, S162C, G196K, H221Y, V245I, A272P, I293V, T296S, E297A, M357MT, G359GS, V381VI |
| >4300-30729| codons 2-399 VSPIKTVPVKLKPGMDGPKVKQWPLTEEKIRALLEICTEMEKEGKISKIGPENPYNTPVF AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAFFSIPLD EDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVIY QYVDDLYVGSDLEIKQHRTKIEELRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWTV QPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLSAEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSAH TNDVKQLTEAVQKIATESIIIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | V11I, L24I, K43KT, L89V | L10I, I13V, L19LI, K20M, L33L_L, M36I, K55R, R57K, L63P, E65EK, C67CY, A71IV, I72L, T91A, Q92QL, F99FL |
| >4300-30729| codons 1-99 PQITLWQRPIITVKIGGQIMEALIDTGADDTVLEEINLPGRWTPKIIGGIGGFVRVKQYD QIPIKIYGHKVLGTVLVGPTPANVIGRNVLALIGCTLNL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |