<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4300 4300-30729 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V V11I, L24I, K43KT, L89V L10I, I13V, L19LI, K20M, L33L_L, M36I, K55R, R57K, L63P, E65EK, C67CY, A71IV, I72L, T91A, Q92QL, F99FL  
>4300-30729| codons 1-99
PQITLWQRPIITVKIGGQIMEALIDTGADDTVLEEINLPGRWTPKIIGGIGGFVRVKQYD
QIPIKIYGHKVLGTVLVGPTPANVIGRNVLALIGCTLNL

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, Y115F, M184V   L100I, K103N   P1L, I2IV, E6EK, K32R, V35L, V118VI, K122E, E138EQ, S162C, G196K, H221Y, V245I, A272P, I293V, T296S, E297A, M357MT, G359GS, V381VI, A400T  
>4300-30729| codons 1-400
LVSPIKTVPVKLKPGMDGPKVKQWPLTEEKIRALLEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAFFSIPL
DEDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIKQHRTKIEELRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLSAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEAVQKIATESIIIWGKTPKFKLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006