Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4295 | 4295-30722 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, L210W, T215Y | D67G, K219N | Y181C | V21I, V35VL, K43E, E44A, K49KR, K64H, K101KQ, V118I, K122E, I135IT, E203EK, H208Y, R211K, K223Q, L228R, P243T, V245KQ, A272P, I293IV, G333E, Q334C, R356K, G359S, V365I, A376T, S379C, V381I, K390R |
| >4295-30722| codons 1-399 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALLEICTELEEAGKISRIGPENPYNTPV FAIHKKGSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDNKHQQEPPFRWMGYELHPDKWT VQTIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQECGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDIKQLTEAVQKITTECIIIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L10F, V11I, L33F, T74P | I13V, K20T, E35N, M36I, N37D, K55R, I62V, L63P, A71V, T91S | C95C* |
| >4295-30722| codons 1-99 PQITLWQRPFITVKIGGQLTEALLDTGADDTVFENIDLPGRWKPKLIGGIGGFVRVRQYD QVPIEICGHKVIGPVLVGPTPVNVIGRNLMSQIG*TLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |