Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4294 | 4294-30929 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, Y115F, Q151M, M184V, T215F | V75I, F77L, F116Y, K219E | Y181C, G190A | V108I | V21VI, T39TA, T69N, W88S, K101Q, K102Q, G112A, K122E, D123E, S162Y, I178L, L205F, F214L, K223KQ, A272P, K277R, A288T, I293IV, E297K, K366R, T386I |
| >4294-30929| codons 1-399 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLIDLRELNKRTQDFSEVQLGIPHPAGLQQKKSVTILDVADAFYSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQYSMTKILEPFRKQNPDLVI CQYVDDLYVASDLEIGQHRTKIEEFRQHLLRWGLFTPDEKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, K43T, G73S, T74TP | L10V, I13V, K14KR, I15IV, L19I, M36L, N37D, K55R, I62V, L63P, C67CF, A71V |
| >4294-30929| codons 1-99 PQITLWQRPVVTVRVGGQIKEALLDTGADDTVFEELDLPGRWTPKLIGGIGGFVRVRQYD QVPIEIFGHKVISPVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |