<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4294 4294-30929 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70KR, Y115F, Q151M, M184V, T215F V75I, F77L, F116Y, K219E Y181C, G190A V108I V21VI, T39TA, T69N, W88S, K101Q, K102Q, G112A, K122E, D123E, S162Y, I178L, L205F, F214L, K223KQ, A272P, K277R, A288T, I293IV, E297K, K366R, T386I  
>4294-30929| codons 1-399
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKLIDLRELNKRTQDFSEVQLGIPHPAGLQQKKSVTILDVADAFYSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQYSMTKILEPFRKQNPDLVI
CQYVDDLYVASDLEIGQHRTKIEEFRQHLLRWGLFTPDEKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L33F, K43T, G73S, T74TP L10V, I13V, K14KR, I15IV, L19I, M36L, N37D, K55R, I62V, L63P, C67CF, A71V  
>4294-30929| codons 1-99
PQITLWQRPVVTVRVGGQIKEALLDTGADDTVFEELDLPGRWTPKLIGGIGGFVRVRQYD
QVPIEIFGHKVISPVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006