Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4292 | 4292-30825 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210*CWY, T215Y | K219R | V106A, G190A | F227L | E6D, V35T, K43KQ, E44D, V60I, V118I, K122E, D123DN, V179I, G196E, T200A, E203V, Q207E, H208FY, R211K, H221Y, A272P, K277R, T286TA, D324E, I329L, A355AT, G359GS, V365I, T369V, A376C |
| >4292-30825| codons 1-400 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASDLEIEQHRAKIVELREYLYKWGFYTPDRKYQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYTRMRSA HTNDIKQLVEAVQKICTESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82A, I84V | L10I, K14R, I15V, K20I, E21Q, Q61G, L63P, A71I, V77I, I85V, I93L |
| >4292-30825| codons 1-99 PQITLWQRPIVTIRVGGQLIQALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFTKVRQYD GIPIEICGHKIIGTVLIGPTPANVVGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |