<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4292 4292-30825 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210*CWY, T215Y V75M, K219R V106A, G190A F227L E6D, V35T, K43KQ, E44D, V60I, V118I, K122E, D123DN, V179I, G196E, T200A, E203V, Q207E, H208FY, R211K, H221Y, A272P, K277R, T286TA, D324E, I329L, A355AT, G359GS, V365I, T369V, A376C  
>4292-30825| codons 1-400
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYVDDLYVASDLEIEQHRAKIVELREYLYKWGFYTPDRKYQKEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYTRMRSA
HTNDIKQLVEAVQKICTESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I54T, V82A, I84V   L10I, K14R, I15V, K20I, E21Q, Q61G, L63P, A71I, V77I, I85V, I93L  
>4292-30825| codons 1-99
PQITLWQRPIVTIRVGGQLIQALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFTKVRQYD
GIPIEICGHKIIGTVLIGPTPANVVGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006