Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4291 | 4291-30730 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_VT, L74V, M184V, L210W, T215FY | A62V | K103N, Y181C | V108VI | E6D, K20R, K43E, E44A, V118I, K122E, I135V, Q174K, N175Y, V189VI, T200A, Q207E, R211K, L228H, V245E, I293V, E297K, D324E, R356K, M357MT, G359GS, T369V, A376N, S379C, T386S, K390R |
| >4291-30730| codons 1-400 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKYPDIVI CQYVDDLYIGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA HTNDVKQLVEAVQKINTECIVIWGKSPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, I84V, L90M | L10F, G73S | I15IV, K20I, M36MI, I62IV, L63P, A71V, I85V, I93L |
| >4291-30730| codons 1-99 PQITLWQRPFVTIKVGGQLIEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |