<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4291 4291-30730 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47IV, I54V, I84V, L90M L10F, G73S I15IV, K20I, M36MI, I62IV, L63P, A71V, I85V, I93L  
>4291-30730| codons 1-99
PQITLWQRPFVTIKVGGQLIEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFVKVRQYD
QVPIEICGHKVISTVLVGPTPVNVVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69T_VT, L74V, M184V, L210W, T215FY A62V K103N, Y181C V108VI E6D, K20R, K43E, E44A, V118I, K122E, I135V, Q174K, N175Y, V189VI, T200A, Q207E, R211K, L228H, V245E, I293V, E297K, D324E, R356K, M357MT, G359GS, T369V, A376N, S379C, T386S, K390R  
>4291-30730| codons 1-400
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKYPDIVI
CQYVDDLYIGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA
HTNDVKQLVEAVQKINTECIVIWGKSPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006