<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4290 4290-30717 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V F53L L10I, G16E, K20R, E35D, M36I, N37NK, P39S, D60E, I62V, L63N, A71V, I72T, T74S, I93L  
>4290-30717| codons 1-99
PQITLWQRPIVTIKIEGQLREALLDTGADDTVLEDIKLSGRWKPKIIGGIGGLVKVRQYE
QVNIEICGHKVTGSVLVGPTPVNVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y       K20R, V21I, V35IM, T39TA, E40F, K43E, K82R, V118I, D121C, K122E, I135T, S162C, D177E, H208Y, R211K, K223KQ, A272P, I293V, D324E, G333D, T377Q, K390R  
>4290-30717| codons 1-400
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
CEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQDQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIAQESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006