Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4289 | 4289-30918 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74I, M184V, T215F | D67T, K219E | K101E, Y181C, G190A | V108I, P225PH | E28K, V35T, T69N, V118I, K122E, V179I, I195L, F214L, L228H, V245E, P294A, E297K, D324E, I329L, G333E, M357T, A360V, K385KR, K390R |
| >4289-30918| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKTSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVASDLELGQHRTKIEELRQHLLRWGLFTPDEKHQKEHPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIALTKEAE LELAENREILKEPVHGVYYDPSKELIAELQKQEQGQWTYQIYQEPFKNLKTGKYARTRGV HTNDVKQLTEAVQKIATESIVIWGRTPKFRLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33LF, G73T | T4TS, L19LV, P39Q, I62V, L63P, A71V, I72ILR, V77VI, I85IV, I93L |
| >4289-30918| codons 1-99 PQISLWQRPFVTIKIGGQVKEALLDTGADDTVFEEMNLQGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVRTTVLIGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |