<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4289 4289-30918 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, L74I, M184V, T215F D67T, K219E K101E, Y181C, G190A V108I, P225PH E28K, V35T, T69N, V118I, K122E, V179I, I195L, F214L, L228H, V245E, P294A, E297K, D324E, I329L, G333E, M357T, A360V, K385KR, K390R  
>4289-30918| codons 1-398
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKTSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
CQYVDDLYVASDLELGQHRTKIEELRQHLLRWGLFTPDEKHQKEHPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIALTKEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQEQGQWTYQIYQEPFKNLKTGKYARTRGV
HTNDVKQLTEAVQKIATESIVIWGRTPKFRLPIQKETW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33LF, G73T T4TS, L19LV, P39Q, I62V, L63P, A71V, I72ILR, V77VI, I85IV, I93L  
>4289-30918| codons 1-99
PQISLWQRPFVTIKIGGQVKEALLDTGADDTVFEEMNLQGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVRTTVLIGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006