<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4288 4288-30709 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L33F, G73T L10I, I13V, K20R, E35D, M36I, N37D, R41K, Q61E, I62V, L63P, A71T, I72V, I93L  
>4288-30709| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKMIGGIGGFVKVRQYD
EVPIEICGHKTVTTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KEGR, L74I, M184V, L210W, T215Y K219Q   A98AG P4T, V35T, T69N, V111I, K122E, D177E, G196E, E203K, Q207E, R211K, A272S, T286TA, A288AT, E312V, D324DE, I326V, I329V, Q334I, R356RK, G359GS, A360T, A371V  
>4288-30709| codons 1-400
PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDIGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKTLTEVIPLTEEAE
LELAENREILKVPVHGVYYDPSKELVAEVQKQGIGQWTYQIYQEPFKNLKTGKYAKMRST
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006