Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4288 | 4288-30709 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, G73T | L10I, I13V, K20R, E35D, M36I, N37D, R41K, Q61E, I62V, L63P, A71T, I72V, I93L |
| >4288-30709| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKMIGGIGGFVKVRQYD EVPIEICGHKTVTTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KEGR, L74I, M184V, L210W, T215Y | K219Q | A98AG | P4T, V35T, T69N, V111I, K122E, D177E, G196E, E203K, Q207E, R211K, A272S, T286TA, A288AT, E312V, D324DE, I326V, I329V, Q334I, R356RK, G359GS, A360T, A371V |
| >4288-30709| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDIGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKTLTEVIPLTEEAE LELAENREILKVPVHGVYYDPSKELVAEVQKQGIGQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |