Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4286 | 4286-30910 | Germany | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54AV, V82F, L90M | L33F, K43T, F53L | L10IV, G16E, L19I, K20R, E35D, M36I, N37T, P39T, R41K, D60E, Q61E, I62V, L63P, I64V, H69Q, A71V, I93L |
| >4286-30910| codons 1-99 PQITLWQRPVVTIKIEGQIREALLDTGADDTVFEDITLTGKWTPKMIGGIGGLVKVRQYE EVPVEICGQKVIGTVLVGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69~, L74V, Y115F, Q151M, M184V, L210W, T215Y | F116Y, K219E | K101E, Y181C, G190S | V108I | V35T, T39A, S48E, V60I, S68G, D123E, R172K, K173A, Q174K, D177E, I178M, G196GE, T200A, Q207A, R211K, H221HY, L228H, P243A, V245Q, E248D, D250S, A272P, K275R, Q278N, T286A, E291D, I293V, E297A, R307RK, D324E, Q334H, G335D, F346H, R356K, M357K, G359S, A371V, I375V, T386I, K390R |
| >4286-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKIEKIGPENPYNTPI FAIKKKNG~KWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAFYSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKAKNPEMVI CQYVDDLYVSSDLEIEQHRAKIEELRAHLWKWGFYTPDEKYQKEPPFHWMGYELHPDKWT VQAIQLPDKSSWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLLRGAKALTDVVPLTAEAE LELAENKEILKEPVHGVYYDPSKELIAEIQKQGHDQWTYQIYQEPHKNLKTGKYAKKRSA HTNDVKQLTEVVQKVATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |