Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4282 | 4282-30731 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | V75L, K219R | V106A, G190A | F227L | V35IL, K43E, E44A, K101Q, V118I, K122E, Q174K, V179VI, H208Y, R211K, K223Q, V245T, T286A, E312N, I329V, A355AS, R356RK, M357T, R358K, K366R, T369A, E370D, A371AV, K395KR |
| >4282-30731| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVLDFRELNKRTQDFWEVQLGIPHPAGLQKKKSATVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIII YQYMDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQQEPPLLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKNPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYSKTKGA HTNDVRQLADVVQKIATESIVIWGKTPKFKLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | I15V, K20I, M36MI, I62V, L63P, A71V, I72T, V77T, I85V, I93L |
| >4282-30731| codons 1-99 PQITLWQRPFVTIKVGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVTTTVLTGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |