<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4282 4282-30731 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y V75L, K219R V106A, G190A F227L V35IL, K43E, E44A, K101Q, V118I, K122E, Q174K, V179VI, H208Y, R211K, K223Q, V245T, T286A, E312N, I329V, A355AS, R356RK, M357T, R358K, K366R, T369A, E370D, A371AV, K395KR  
>4282-30731| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKVLDFRELNKRTQDFWEVQLGIPHPAGLQKKKSATVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIII
YQYMDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQQEPPLLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKNPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYSKTKGA
HTNDVRQLADVVQKIATESIVIWGKTPKFKLPIQRETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73T I15V, K20I, M36MI, I62V, L63P, A71V, I72T, V77T, I85V, I93L  
>4282-30731| codons 1-99
PQITLWQRPFVTIKVGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVTTTVLTGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006