<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4279 4279-30919 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215Y K219E, N348I K101E, Y188L E138K V35I, T39A, V60I, A98S, K122E, I135V, T139L, I142T, D177EG, I178IV, V179VI, I202V, Q207E, H208Y, R211K, D218DE, L228HR, A272P, T286TP, V292I, E297AT, V317VA, I326V, I329V, Q334L, A360T, K390R  
>4279-30919| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNKLPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGVII
YQYMDDLLVGSDLEIGQHRTKVEELREYLLKWGFYTPEEKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEIIPLTTEAE
LELAENREILKEPVHGAYYDPSKDLVAEVQKQGLGQWTYQIYQEPFKILKTGKYARMRGT
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82C, I84V, L90M L10F, L33F, F53L, T74P K14R, E34Q, N37D, R41K, K55R, Q61E, I62V, L63P, A71V, V77I, P79D, I93L  
>4279-30919| codons 1-99
PQITLWQRPFVTIRIGGQLKEALLDTGADDTVFQEMDLPGKWKPKMIGGIGGLVRVRQYD
EVPIEICGHKVIGPVLIGDTPCNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006