Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4279 | 4279-30919 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82C, I84V, L90M | L10F, L33F, F53L, T74P | K14R, E34Q, N37D, R41K, K55R, Q61E, I62V, L63P, A71V, V77I, P79D, I93L |
| >4279-30919| codons 1-99 PQITLWQRPFVTIRIGGQLKEALLDTGADDTVFQEMDLPGKWKPKMIGGIGGLVRVRQYD EVPIEICGHKVIGPVLIGDTPCNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219E, N348I | K101E, Y188L | E138K | V35I, T39A, V60I, A98S, K122E, I135V, T139L, I142T, D177EG, I178IV, V179VI, I202V, Q207E, H208Y, R211K, D218DE, L228HR, A272P, T286TP, V292I, E297AT, V317VA, I326V, I329V, Q334L, A360T, K390R |
| >4279-30919| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNKLPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGVII YQYMDDLLVGSDLEIGQHRTKVEELREYLLKWGFYTPEEKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEIIPLTTEAE LELAENREILKEPVHGAYYDPSKDLVAEVQKQGLGQWTYQIYQEPFKILKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |