Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2100 | CA7751 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 46 |
| 2 | DDC | 53 |
| 3 | D4T | 91 |
| 4 | 3TC+D4T+IDV | 52 |
| 5 | DLV+AZT+NFV+SQV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, L90M | K20R, E35D, M36I, Q61E, I62V, L63P, I66F, A71T, I72T |
| >CA7751| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTILEDINLPGRWKPKMIGGIGGFIKVRQYD EVPIEFCGHKTTGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, T215Y | D67G | L100I, M230L | V179D | V35I, K103R, K122E, I202V, Q207QH, R211K, T240K |
| >CA7750| codons 1-290 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKGSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI YQYVDDLYVGSDLEIGQHRTKVEELRHHLLKWGFYTPDKKHQKEPPFLWLGYELHPDKWK VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALT |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |