<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2100 CA7751 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 46
2 DDC 53
3 D4T 91
4 3TC+D4T+IDV 52
5 DLV+AZT+NFV+SQV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, L90M   K20R, E35D, M36I, Q61E, I62V, L63P, I66F, A71T, I72T  
>CA7751| codons 1-99
PQITLWQRPLVTIKIGGQLREALLDTGADDTILEDINLPGRWKPKMIGGIGGFIKVRQYD
EVPIEFCGHKTTGTVLVGPTPVNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74I, M184V, T215Y D67G L100I, M230L V179D V35I, K103R, K122E, I202V, Q207QH, R211K, T240K  
>CA7750| codons 1-290
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKGSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI
YQYVDDLYVGSDLEIGQHRTKVEELRHHLLKWGFYTPDKKHQKEPPFLWLGYELHPDKWK
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALT

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005