Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4277 | 4277-30626 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | A98S, D123E, G196E, Q207H, F214L, V245A, A272P, K281R, T286A, E297K, V314VI, V317A, S322T, Q334L, R358K, K366R, T369V, A371V, I375V, A376T, T377M, K390R, E399D | G152GR |
| >4277-30626| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQRWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRHHLLRWGLFTPDEKHQKEPPFLWMGYELHPDKWT VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPIHGAYYDPTKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVRQLVEVVQKVTMESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13IM, L19LP, N37D, K43R, D60DE, Q61QE, I62V, L63S, I93L |
| >4277-30626| codons 1-99 PQITLWQRPIVTMKIGGQPKEALLDTGADDTVLEEMDLPGRWRPKMIGGIGGFIKVRQYE EVSIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |