Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4267 | 4267-40518 | Germany | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54T, V82VL, I84V, L90M | L33I | L10I, I13V, K20I, E34Q, E35G, M36I, L63P, I64V, T74S |
| >4267-40518| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVIQGINLPGRWKPKIIGGIGGFTKVRQYD QIPVEICGHKAIGSVLVGPTPLNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75M, M184V, T215Y | K219Q | K101P, G190A | Y318F | E6N, V35I, K43Q, E44D, K73M, I94L, V118I, K122E, D123E, S162D, D177E, I178M, V179I, E203G, Q207E, H208Y, L210Y, R211K, D218E, L228H, Q242H, V245K, I293V, R358K, I375V, A376S, T386I, K390R, K395R, E399D | I159L |
| >4267-40518| codons 1-400 PISPINTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTRWRMIMDFRELNKRTQDFWEVQLGLPHPAGLPKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPALFQDSMTKILEPFRKQNPEMII YQYVDDLYVASDLEIGQHRTKIGELREYLYKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VHPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKVSTESIVIWGKIPKFRLPIQRETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |